产品货号：
GS4659
中文名称：
重组人IL-36β(153a.a.)
英文名称：
Recombinant Human Interleukin-36 beta, 153a.a.
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 17.2kDa,a single non-glycosylated polypeptide chain containing 153 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36 beta is reported to be expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin and it can stimulate production of interleukin-6 and interleukin-8 in synovial fibrobasts,articular chondrocytes and mature adipocytes.It has two isoforms.IL-36β isoform 2 contains one potential N-linked glycosylation site in its C-terminus,while IL-36β isoform 1 lacks potential N-linked glycosylation sites and four of the conserved β-strands.Human IL-36β isoform 2 shares 62%,67%,63%and 59%a.a.identity with the most similar isoform of mouse,canine,bovine and equine IL-36β,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IL-36β(153a.a.)，IL-36β, 153a.a., Human，Recombinant Human Interleukin-36 beta, 153a.a.
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36 beta is reported to be expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin and it can stimulate production of interleukin-6 and interleukin-8 in synovial fibrobasts,articular chondrocytes and mature adipocytes.It has two isoforms.IL-36β isoform 2 contains one potential N-linked glycosylation site in its C-terminus,while IL-36β isoform 1 lacks potential N-linked glycosylation sites and four of the conserved β-strands.Human IL-36β isoform 2 shares 62%,67%,63%and 59%a.a.identity with the most similar isoform of mouse,canine,bovine and equine IL-36β,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by inducing IL-8 secretion in human preadipocytes is less than 10ng/ml,corresponding to a specific activity of>1.0×105 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 2×PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuIL-36β,153a.a.as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | REAAPKSYAI RDSRQMVWVL SGNSLIAAPL SRSIKPVTLH LIACRDTEFS DKEKGNMVYL GIKGKDLCLF CAEIQGKPTL QLKEKNIMDL YVEKKAQKPF LFFHNKEGST SVFQSVSYPG WFIATSTTSG QPIFLTKERG ITNNTNFYLD SVE |
相关搜索：重组人IL-36β(153a.a.)，IL-36β, 153a.a., Human，Recombinant Human Interleukin-36 beta, 153a.a.